Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding
نویسندگان
چکیده
منابع مشابه
Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding.
OBJECTIVE To determine whether the use of mixed micellar vitamin K improves the efficacy of the 3 x 2 mg oral vitamin K prophylaxis schedule. DESIGN Nationwide active surveillance for vitamin K deficiency bleeding (VKDB) complemented with two surveys on the use of the mixed micellar preparation in hospitals and by paediatricians. SETTING AND PATIENTS Infants in Germany in 1997-2000. INTER...
متن کامل[Prophylactic vitamin K for vitamin K deficiency bleeding of the newborn].
BACKGROUND The administration of vitamin K immediately after birth has shown a significant decrease in the incidence of newborn bleeding, but there is not enough evidence to determine the most appropriate method of administration. The objective of this review is to determine the effectiveness of orally administered vitamin K compared to the intramuscular route in the prevention of hemorrhagic d...
متن کاملLate Vitamin K Deficiency Bleeding in Infants Whose Parents Declined Vitamin K Prophylaxis — Tennessee, 2013
Vitamin K deficiency bleeding (VKDB) is a coagulopathy that develops in infants who do not have sufficient vitamin K stores to support production of clotting factors. In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in humans is limited; cord blood and infant liver reserve levels of vitamin K are substantially below adult lev...
متن کاملA case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K
Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...
متن کاملVitamin K Deficiency Disease
Vitamin Kdeficiency bleeding (VKDB) previously known as hemorrhagic disease of the newborn has been classified as Early (0-24hrs), Classic (2-7 days) and Late (1-6 months). Child birth following the maternal ingestion of anti-epileptic drugs such as Phenytoin, is liable to result in early VKDB as well as bone changes in the fetus. Other maternal risk factors for VKDB include medications such as...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2018
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2018.02.031